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INHIBITORY EFFECT OF CYCLOSPORINE-A ON ERYTHROID AND STROMAL COLONIES

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CLARKE, E, Quinn, Daniel and MCCANN, SR (1991) INHIBITORY EFFECT OF CYCLOSPORINE-A ON ERYTHROID AND STROMAL COLONIES. EUROPEAN JOURNAL OF HAEMATOLOGY, 47 (4). pp. 282-286. [Journal article]

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Abstract

Cyclosporin A is used to prevent graft-versus-host disease (GvHD) following bone marrow transplantation (BMT) and it has been implicated in reducing the time to engraftment for leukaemia and aplastic anaemia patients. To evaluate the effect of cyclosporin A on engraftment, the proliferative capacity of bone marrow progenitors (CFU-E, CFU-F and CFU-C) was assessed both in vitro and following treatment with cyclosporin A over a 9-week period using an animal model. Cyclosporin had a differential effect on the haemopoietic progenitors, with the myeloid series unaffected at therapeutic concentrations. Both erythroid and stromal progenitors were significantly inhibited at similar concentrations. The mechanism by which cyclosporin A enhances engraftment remains unclear; however, it is not mediated by enhancing any of the haemopoietic progenitors.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
ID Code:22909
Deposited By:Dr Daniel Quinn
Deposited On:31 Jul 2012 12:19
Last Modified:31 Jul 2012 12:19

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