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INVIVO STUDIES OF THE ACTION SPECTRUM AND TIME COURSE FOR RELEASE OF TRANSFORMING GROWTH FACTOR-ALPHA BY ULTRAVIOLET-IRRADIATION IN MAN

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

MURPHY, GM, Quinn, Daniel, CAMP, RDR, HAWK, JLM and GREAVES, MW (1991) INVIVO STUDIES OF THE ACTION SPECTRUM AND TIME COURSE FOR RELEASE OF TRANSFORMING GROWTH FACTOR-ALPHA BY ULTRAVIOLET-IRRADIATION IN MAN. BRITISH JOURNAL OF DERMATOLOGY, 125 (6). pp. 566-568. [Journal article]

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DOI: 10.1111/j.1365-2133.1991.tb14795.x

Abstract

Transforming growth factor-alpha (TGF-alpha) is a growth-promoting cytokine which enhances epithelial proliferation and is secreted by a wide variety of tumour cells. It is also present in normal human epidermis and its overproduction may be responsible for epidermal hyperproliferation in psoriasis. Ultraviolet (UV) B irradiation of human skin leads to epidermal damage and significant subsequent hyperplasia after approximately 24 h, whereas UVA irradiation has little such effect and predominantly damages the dermis. The relative efficacies of UVB and UVA in releasing TGF-alpha were studied in 10 subjects of skin types I and II using a skin-chamber technique and a specific TGF-alpha radioimmunoassay. Significantly elevated concentrations of immunoreactive TGF-alpha were detected in samples after 24 h in UVB-irradiated compared with unirradiated skin. Samples at earlier time points from UVB- and UVA-exposed skin contained measurable levels of TGF-alpha but these were not significantly elevated above the levels found in samples from unirradiated areas. These results, which suggest that UVB irradiation increases release of TGF-alpha from human skin at 24 h, indicate that TGF-alpha may be implicated in UVB-induced epidermal hyperplasia.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
ID Code:22908
Deposited By:Dr Daniel Quinn
Deposited On:31 Jul 2012 12:18
Last Modified:31 Jul 2012 12:18

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