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Polyethylene glycol functionalized gold nanoparticles:the influence of capping density on stability in various media

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Dixon, D, Meenan, BJ, Manson, J and Kumar, D (2011) Polyethylene glycol functionalized gold nanoparticles:the influence of capping density on stability in various media. Gold Bulletin , 44 (2). pp. 99-105. [Journal article]

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URL: http://www.springerlink.com/content/977q420146061326/

DOI: 10.1007/s13404-011-0015-8

Abstract

Thiol-terminated polyethylene glycol (PEG) iscommonly used to functionalize the surface of gold nanoparticles(AuNPs) in order to improve their in vivo stabilityand to avoid uptake by the reticular endothelial system.Although it has been reported that AuNPs functionalized withtethered PEG are stable in biological media, the influence ofchain density remains unclear. This study investigates theinfluence of PEG capping density on the stability of washedand dried AuNPs in: water, phosphate-buffered saline solution(PBS), phosphate-buffered saline solution containing bovineserum albumin (PBS/BSA), and dichloromethane (DCM).PEG coating had a dramatic effect on stability enabling stablesuspensions to be produced in all the media studied. A linearrelationship was observed between capping density andstability in water and DCM with a somewhat lower stabilityobserved in PBS and PBS/BSA. A maximum PEG loadinglevel of ∼14 wt.% was achieved, equivalent to a PEG surfacedensity of ∼1.13 chains/nm2.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:22770
Deposited By:Dr Dorian Dixon
Deposited On:09 Jul 2012 16:19
Last Modified:09 Jul 2012 16:19

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