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Microbubble-enhanced ultrasound-mediated gene transfer - Towards the development of targeted gene therapy for cancer

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Nomikou, Nikoleta and MCHALE, AP (2012) Microbubble-enhanced ultrasound-mediated gene transfer - Towards the development of targeted gene therapy for cancer. Int. J. Hyperthermia, 28 (4). pp. 300-310. [Journal article]

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URL: http://informahealthcare.com/doi/abs/10.3109/02656736.2012.659235

DOI: 10.3109/02656736.2012.659235


Ultrasound-mediated gene transfer is emerging as a possible alternative to viral gene transfer, and pre-clinical data suggest that it may play a significant role in gene therapy-based approaches to the treatment of disease. As an extracorporeal stimulus, ultrasound can non-invasively and transiently compromise cell membrane permeability (sonoporation), thereby offering the promise of delivering either genes or oligonucleotide-based therapeutics to cells and tissues in a site-specific manner. The membrane-permeabilising effects of ultrasound can be greatly enhanced using microbubble preparations, many of which have, in the past, found application as ultrasound contrast agents. Because these ultrasound-responsive agents are highly amenable to surface modification it has been suggested that they may be exploited as ultrasound-responsive nucleic acid delivery vehicles. In this article we seek to explore the potential role ultrasound, in combination with microbubble-based agents, may play in providing site-specific gene therapy-based approaches for the treatment of cancer.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:22574
Deposited By:Professor Anthony McHale
Deposited On:11 Jun 2012 14:48
Last Modified:29 Nov 2012 12:29

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