Casanueva Marenco, Maria Jose, Fowley, Colin, Hyland, Barry W., Hamilton, Graham R. C., Galindo-Riano, Dolores and Callan, John F. (2012) A new use for an old molecule: N-phenyl-2-(2-hydroxynaphthalen-1-ylmethylene)hydrazinecarbothioamide as a ratiometric `Off-On' fluorescent probe for iron. TETRAHEDRON LETTERS, 53 (6). pp. 670-673. [Journal article]
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N-Phenyl-2-(2-hydroxynaphthalen-1-ylmethylene)hydrazinecarbothioamide has been investigated as a fluorescent sensor for the determination of Fe(III) in aqueous solutions. The probe was prepared by the facile Schiff base condensation of 2-hydroxy-1-napthaldehyde with N-phenylhydrazinecarbothioamide. The sensor displayed good selectivity for Fe(III) when tested against a range of biologically and environmentally important cations. A concentration dependent increase in the emission of two fluorescent bands at 425 and 495 nm was observed upon increasing Fe(III) addition resulting in a linear ratiometric response in the 17-37 mu M range. The binding stoichiometry was confirmed as 1:1 (host/guest) with the binding constant (log beta) calculated as 4.56. (C) 2011 Elsevier Ltd. All rights reserved.
|Item Type:||Journal article|
|Keywords:||Fluorescence; Sensor; Iron(III); Ratiometric|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
|Deposited By:||Professor John Callan|
|Deposited On:||11 Jun 2012 14:50|
|Last Modified:||19 Nov 2012 14:58|
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