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Chickpea (Cicer arietinum) and Other Plant-Derived Protease Inhibitor Concentrates Inhibit Breast and Prostate Cancer Cell Proliferation In Vitro.

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Magee, Pamela, Owusu, Richard, McCann, Mark, Gill, Chris I. R. and Rowland, Ian R (2012) Chickpea (Cicer arietinum) and Other Plant-Derived Protease Inhibitor Concentrates Inhibit Breast and Prostate Cancer Cell Proliferation In Vitro. Nutrition and Cancer, 1-8 . [Journal article]

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URL: http://www.tandfonline.com/doi/pdf/10.1080/01635581.2012.688914

DOI: 10.1080/01635581.2012.688914

Abstract

The soybean-derived protease inhibitor, Bowman-Birk inhibitor(BBI), is currently showing great promise as a novel cancerchemopreventive agent. In contrast to the wealth of researchconducted on this compound, the anticancer effects of proteaseinhibitors isolated from other leguminous sources have receivedlimited attention. In the current study, 7 protease inhibitor concentrates(PICs) were isolated from various leguminous sources(including soybean) and characterized. The effects of PICs on theproliferation of breast and prostate cancer cells were investigatedin vitro. Chickpea PIC significantly inhibited the viability ofMDAMB-231 breast cancer and PC-3 and LNCaP prostate cancer cellsat all concentrations tested (25–400 μg/ml). In addition, kidneybean (200, 400 μg/ml), soybean (50, 100 μg/ml), and mungbean(100, 200 μg/ml) PICs inhibited LNCaP cell viability. These findingssuggest that leguminous PICs may possess similar anticancerproperties to that of soybean BBI and deserve further study aspossible chemopreventive agents.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:22476
Deposited By:Dr Pamela Magee
Deposited On:11 Jun 2012 14:53
Last Modified:11 Jun 2012 14:53

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