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Antimicrobial properties of protein extracts from wild mushroom fungi and native plant species against hospital pathogens

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Hearst, Michael, Nelson, David, McCollum, Graham, Ballard, Linda M., Millar, B. Cherie, Moore, Sara, McClean, Stephen, Moore, John E. and Rao, Juluri R. (2010) Antimicrobial properties of protein extracts from wild mushroom fungi and native plant species against hospital pathogens. Journal of Pharmacognosy and Phytotherapy, 2 (8). pp. 103-107. [Journal article]

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URL: http://www.academicjournals.org/jpp/abstracts/abstracts/abstracts2010/Dec/Hearst%20et%20al.htm

Abstract

Protein extracts of either native or exotic rare mushroom fungi and plants that are normally known for novel therapeutics including immune modulation were investigated for their potential antimicrobial effects. Data obtained using the Kirby-Bauer’s disc-diffusion assay methods showed that a number of locally sourced wild mushroom fungi (e.g. Ganoderma resinaceum, Russula fragilis and Inocybe grammata) had proteins with inherent antimicrobial properties against a number of typical hospital pathogens. The wild type fungus Mycena pura exhibited strong antagonism against Escherichia coli, an organism often commonly associated with nosocomial infections both locally and worldwide. Polyacrylamide gel electrophoresis (PAGE) of protein extracts revealed unique protein banding patterns for the exotic fungal species and possessed significant inhibitory effects against a range of nosocomial pathogens including MRSA, Salmonella, Candida and Aspergillus species. This small-scale study revealed the occurrence of wild fungal peptides of potential therapeutic significance and antimicrobial potential for exploitation in complementary therapies in clinical and veterinary medicine.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:22277
Deposited By:Dr Stephen McClean
Deposited On:17 May 2012 09:17
Last Modified:17 May 2012 09:17

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