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Dimensions of a projection column and architecture of VPM and POm axons in rat vibrissal cortex.

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Wimmer, Verena C, Bruno, Randy M, Kock, Christiaan P J, Kuner, Thomas and Sakmann, Bert (2010) Dimensions of a projection column and architecture of VPM and POm axons in rat vibrissal cortex. Cereb Cortex, 20 (10). pp. 2265-2276. [Journal article]

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URL: http://dx.doi.org/10.1093/cercor/bhq068

DOI: 10.1093/cercor/bhq068

Abstract

This is the first article in a series of 3 studies that investigate the anatomical determinants of thalamocortical (TC) input to excitatory neurons in a cortical column of rat primary somatosensory cortex (S1). S1 receives 2 major types of TC inputs, lemiscal and paralemniscal. Lemiscal axons arise from the ventral posteromedial nucleus (VPM) of the thalamus, whereas paralemniscal fibers originate in the posteromedial nucleus (POm). While these 2 TC projections are largely complementary in L4, overlap in other cortical layers is still a matter of debate. VPM and POm axons were specifically labeled in the same rat by virus-mediated expression of different fluorescent proteins. We show that columnar and septal projection patterns are maintained throughout most of the cortical depth with a lower degree of separation in infragranular layers, where TC axons form bands along rows. Finally, we present anatomical dimensions of "TC projection domains" for a standard column in S1.

Item Type:Journal article
Keywords:Analysis of Variance; Animals; Animals, Newborn; Axons, physiology/ultrastructure; Cell Count, methods; Dependovirus, physiology; Green Fluorescent Proteins, genetics; Luminescent Proteins, genetics; Microscopy, Confocal, methods; Neural Pathways, physiology; Posterior Thalamic Nuclei, cytology; Presynaptic Terminals, physiology; Rats; Sensory Receptor Cells, physiology; Somatosensory Cortex, anatomy /&/ histology; Ventral Thalamic Nuclei, cytology; Vibrissae, innervation
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
ID Code:22135
Deposited By:Dr Kurt Saetzler
Deposited On:15 May 2012 12:57
Last Modified:15 May 2012 12:57

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