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Platelet adhesion on silicon modified hydrogenated amorphous carbon films

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Okpalugo, TIT, Ogwu, AA, Maguire, PD and McLaughlin, JAD (2004) Platelet adhesion on silicon modified hydrogenated amorphous carbon films. BIOMATERIALS, 25 (2). pp. 239-245. [Journal article]

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URL: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TWB-49C5F4S-5-17&_cdi=5558&_user=126978&_orig=search&_coverDate=01%2F31%2F2004&_sk=999749997&view=c&wchp=dGLbVtb-zSkzV&md5=ca3f0c4d2ddcffe21d07b1ffc2e620a5&ie=/sdarticle.pdf

DOI: 10.1016/S0142-9612(03)00494-0


We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electronspectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of < 0.05. (C) 2003 Elsevier Ltd. All rights reserved.

Item Type:Journal article
Keywords:Si-DLC; Raman spectroscopy; haemocompatibility; contact angle/surface energy; work function/semi-conduction; human platelet aggregation
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:218
Deposited By:Mrs Ann Blair
Deposited On:01 Sep 2009 14:55
Last Modified:21 Feb 2014 15:22

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