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Platelet adhesion on silicon modified hydrogenated amorphous carbon films

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Okpalugo, TIT, Ogwu, AA, Maguire, PD and McLaughlin, JAD (2004) Platelet adhesion on silicon modified hydrogenated amorphous carbon films. BIOMATERIALS, 25 (2). pp. 239-245. [Journal article]

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URL: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TWB-49C5F4S-5-17&_cdi=5558&_user=126978&_orig=search&_coverDate=01%2F31%2F2004&_sk=999749997&view=c&wchp=dGLbVtb-zSkzV&md5=ca3f0c4d2ddcffe21d07b1ffc2e620a5&ie=/sdarticle.pdf

DOI: 10.1016/S0142-9612(03)00494-0

Abstract

We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electronspectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of < 0.05. (C) 2003 Elsevier Ltd. All rights reserved.

Item Type:Journal article
Keywords:Si-DLC; Raman spectroscopy; haemocompatibility; contact angle/surface energy; work function/semi-conduction; human platelet aggregation
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:218
Deposited By:Mrs Ann Blair
Deposited On:01 Sep 2009 14:55
Last Modified:21 Feb 2014 15:22

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