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OVERLAPPING PATTERNS OF IGF2 AND H19 EXPRESSION DURING HUMAN-DEVELOPMENT - BIALLELIC IGF2 EXPRESSION CORRELATES WITH A LACK OF H19 EXPRESSION

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

OHLSSON, R, HEDBORG, F, HOLMGREN, L, Walsh, Colum and EKSTROM, TJ (1994) OVERLAPPING PATTERNS OF IGF2 AND H19 EXPRESSION DURING HUMAN-DEVELOPMENT - BIALLELIC IGF2 EXPRESSION CORRELATES WITH A LACK OF H19 EXPRESSION. DEVELOPMENT, 120 (2). pp. 361-368. [Journal article]

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Abstract

The spatial patterns of IGF2 and H19 gene expression are strikingly similar during parts of human embryonic/fetal and early postnatal development. Notable exceptions were found with the ciliary anlage of the embryonic retina and the choroid plexus/leptomeninges, where transcripts from the IGF2 but not the H19 locus could be detected. Moreover, in contrast to the other tissue samples examined, the choroid plexus/leptomeninges expressed both parental IGF2 alleles. Whilst RNase protection analysis revealed a weak activity of the P1 promoter in the choroid plexus/leptomeninges, the P2, P3 and P4 promoters were all active wherever IGF2 was expressed. We discuss these observations with respect to a hypothesized coordinated control of the reciprocally imprinted and closely linked IGF2 and H19 loci.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Transcriptional Regulation & Epigenetics
ID Code:21703
Deposited By:Professor Colum Walsh
Deposited On:02 Apr 2012 11:07
Last Modified:11 Dec 2012 15:40

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