OHLSSON, R, HEDBORG, F, HOLMGREN, L, Walsh, Colum and EKSTROM, TJ (1994) OVERLAPPING PATTERNS OF IGF2 AND H19 EXPRESSION DURING HUMAN-DEVELOPMENT - BIALLELIC IGF2 EXPRESSION CORRELATES WITH A LACK OF H19 EXPRESSION. DEVELOPMENT, 120 (2). pp. 361-368. [Journal article]
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The spatial patterns of IGF2 and H19 gene expression are strikingly similar during parts of human embryonic/fetal and early postnatal development. Notable exceptions were found with the ciliary anlage of the embryonic retina and the choroid plexus/leptomeninges, where transcripts from the IGF2 but not the H19 locus could be detected. Moreover, in contrast to the other tissue samples examined, the choroid plexus/leptomeninges expressed both parental IGF2 alleles. Whilst RNase protection analysis revealed a weak activity of the P1 promoter in the choroid plexus/leptomeninges, the P2, P3 and P4 promoters were all active wherever IGF2 was expressed. We discuss these observations with respect to a hypothesized coordinated control of the reciprocally imprinted and closely linked IGF2 and H19 loci.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Transcriptional Regulation & Epigenetics
|Deposited By:||Professor Colum Walsh|
|Deposited On:||02 Apr 2012 11:07|
|Last Modified:||11 Dec 2012 15:40|
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