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A study of anti-cancer effects of Funalia trogii in vitro and in vivo

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Worthington, Jenny, McKeown, Stephanie and Banat, Ibrahim (2011) A study of anti-cancer effects of Funalia trogii in vitro and in vivo. Food and Chemical Toxicology, 49 (7). pp. 1477-1483. [Journal article]

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URL: http://dx.doi.org/10.1016/j.fct.2011.02.008

DOI: 10.1016/j.fct.2011.02.008

Abstract

Extracts of natural products have been used for many years for health benefits. We report on an in vitro and in vivo study into the anti-tumour efficacy of an aqueous extract of the mycelial form of basidiomycete, Funalia trogii. A variety of biological assays were used to show that a 4 h exposure of HT29, LNCaP, PC3, MCF-7 and MDA-MB-231 tumour cells to extract (0.5–5.0 mg/ml) resulted in significant cytotoxicity. In a clonogenic assay, IC50 values were found to range from 0.4–0.72 mg/ml; exposing fibroblast cells to the extract resulted in no cell kill. The extract resulted in significant cell kill in proliferating endothelial cells but had no toxicity to quiescent cells, this is useful in targeting tumour tissue since endothelial cells in tumours proliferate more rapidly that those found in other parts of the body. When tumours grown in immune compromised mice were injected intratumourally with extract (5 mg/ml twice a week for twoweeks), a 9 day tumour growth delay was observed. The results indicate that the mycelial extract of F. trogii has a promising anti-tumour property.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences > School of Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
Institute of Nursing and Health Research > Centre for Health and Rehabilitation Technologies
ID Code:21533
Deposited By:Professor Ibrahim Banat
Deposited On:23 Mar 2012 11:25
Last Modified:07 Apr 2014 11:04

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