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Electric field-enhanced activation of hematoporphyrin derivative: Effects on a human tumour cell line

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Ward, T, Mooney, D, Flynn, G and McHale, AP (1997) Electric field-enhanced activation of hematoporphyrin derivative: Effects on a human tumour cell line. CANCER LETTERS, 113 (1-2). pp. 145-151. [Journal article]

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DOI: 10.1016/S0304-3835(96)04592-2

Abstract

In a recent report we described the effects of combined electroactivation and photoactivation of hematoporphyrin derivative (HPD) on human erythrocytes and established that activation-induced cell lysis was more pronounced when both modes of activation were sequentially applied to the system. Here we demonstrate that electric field-induced activation of HPD-treated HeLa cells results in cell death, This effect is shown to be dependant on both electric field strength and on HPD concentration. In addition, we demonstrate that exposure of HPD-treated cells to shea and intense electric pulses prior to photoactivation, results in increased cell mortality. The results confirm our earlier suggestion that HPD may be activated in the presence of an applied electric field, The results further suggest that activation of photosensitizers using combined exposure to electric fields and light may play an important role in increasing the efficiency of photodynamic therapy (PDT) in the treatment of cancer. (C) 1997 Elsevier Science Ireland Ltd.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:21523
Deposited By:Professor Anthony McHale
Deposited On:28 Mar 2012 16:20
Last Modified:04 Dec 2012 11:46

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