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MAGNETICALLY RESPONSIVE PHOTOSENSITIZING REAGENTS FOR POSSIBLE USE IN PHOTORADIATION THERAPY

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

FLYNN, G, HACKETT, TJ, MCHALE, L and MCHALE, AP (1994) MAGNETICALLY RESPONSIVE PHOTOSENSITIZING REAGENTS FOR POSSIBLE USE IN PHOTORADIATION THERAPY. CANCER LETTERS, 78 (1-3). pp. 109-114. [Journal article]

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DOI: 10.1016/0304-3835(94)90038-8

Abstract

The ability of a magnetically responsive material to function as a carrier for photosensitizing agents for use in photoradiation therapy (PRT) has been examined in vitro. The photosensitizer has been attached to the magnetically responsive matrix (Dynabeads) by non-specific adsorption, Intralipid-mediated adsorption and poly-L-lysine mediated adsorption. In these studies, it has been demonstrated that conditions of attachment of photosensitizer to the matrix may be adapted in order to facilitate a diffuse or highly localized photo-toxic effect on target cells in vitro. The authors believe that this system may represent a novel approach to targeting photosensitizing agents to specific areas, thereby circumventing some of the problems associated with conventional photoradiation therapy (PRT), particularly in hollow organs.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:21516
Deposited By:Professor Anthony McHale
Deposited On:28 Mar 2012 16:16
Last Modified:04 Dec 2012 12:00

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