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Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

McCaughan, Bridgeen, Rouanet, C, Fowley, Colin, Nomikou, N, McHale, Anthony and Callan, John (2011) Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs. Bioorganic and Medicinal Chemistry Letters, 21 (19). pp. 5750-5752. [Journal article]

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DOI: 10.1016/j.bmcl.2011.08.015

Abstract

A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:21291
Deposited By:Professor Anthony McHale
Deposited On:05 Mar 2012 11:22
Last Modified:13 May 2014 14:23

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