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Structural changes in the hippocampus and amygdala at first episode of psychosis.

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Watson, David R, Bai, Feng, Barrett, Suzanne L, Turkington, Aidan, Rushe, Teresa M, Mulholland, Ciaran C and Cooper, Stephen J (2012) Structural changes in the hippocampus and amygdala at first episode of psychosis. Brain imaging and behavior, 6 (1). pp. 49-60. [Journal article]

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Abstract

Hippocampus and amygdala changes have been implicated in the pathophysiology and symptomatology of both schizophrenia (SCZ) and bipolar disorder (BD). However relationships between illness course, neuropathological changes and variations in symptomatology remain unclear. This investigation examined the associations between hippocampus and amygdala volumes and symptom dimensions in schizophrenia and bipolar disorder patients after their first episode of psychosis. Symptom severity was associated with decreases in hippocampus/amygdala complex volume across groups. In keeping with previous work bilateral hippocampus and amygdala volume reductions were also identified in the SCZ patients while in BD patients only evidence of amygdala inflation reached significance. The study concludes that there appear to be important relationships between volume changes in the hippocampus and amygdala and dimensions and severity of symptomatology in psychosis. Structural alterations are apparent in both SCZ and BD after first episode of psychosis but present differently in each illness and are more severe in SCZ.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
ID Code:21280
Deposited By:Dr Teresa Rushe
Deposited On:21 Mar 2012 11:06
Last Modified:21 Mar 2012 11:07

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