Ulster University Logo

Ulster Institutional Repository

Employing neuronal networks to investigate the pathophysiological basis of abnormal cortical oscillations in Alzheimer's disease.

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Abuhassan, Kamal, Coyle, DH and Maguire, LP (2011) Employing neuronal networks to investigate the pathophysiological basis of abnormal cortical oscillations in Alzheimer's disease. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2011 . pp. 2065-8. [Journal article]

Full text not available from this repository.

Abstract

This paper describes an investigation into the pathophysiological causes of abnormal cortical oscillations in Alzheimer's disease (AD) using two heterogeneous neuronal network models. The effect of excitatory circuit disruption on the beta band power (13-30 Hz) using a conductance-based network model of 200 neurons is assessed. Then, the neural correlates of abnormal cortical oscillations in different frequency bands based on a larger network model of 1000 neurons consisting of different types of cortical neurons is also analyzed. The results show that, despite the heterogeneity of the network models, the beta band power is significantly affected by excitatory neural and synaptic loss. Secondly, the results of modeling a functional impairment in the excitatory circuit shows that beta band power exhibits the most decrease compared with other bands. Previous biological experiments on different types of cultural excitatory neurons show that cortical neuronal death is mediated by dysfunctional ionic behavior that might specifically contribute to the pathogenesis of p-amyloid peptide (Ap)-induced neuronal death in AD. Our study also shows that beta band power was the first affected component when the modeled excitatory circuit begins to lose neurons and synapses. Alpha (8-12 Hz), gamma (30-50 Hz) and Full frequency (1-70 Hz) band power are affected in a later stage when more severe synaptic loss occurs.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Computing and Intelligent Systems
Research Institutes and Groups:Computer Science Research Institute
Computer Science Research Institute > Intelligent Systems Research Centre
ID Code:21067
Deposited By:Dr Damien Coyle
Deposited On:14 Feb 2012 16:49
Last Modified:14 Feb 2012 16:49

Repository Staff Only: item control page