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Osteoblast-like cell response to calcium phosphate coatingchemistry and morphology on etched silicon surfaces

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Burke, G, Rea, C, Horgan, F, Turkington, M, Boyd, AR and Meenan, BJ (2012) Osteoblast-like cell response to calcium phosphate coatingchemistry and morphology on etched silicon surfaces. Journal of Materials Science:Materials in Medicine, Journal no. 10856 . pp. 835-851. [Journal article]

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URL: http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.1007/s10856-011-4542-x&cm_mmc=event-_-articleAuthor-_-onlineFirst-_-0

DOI: DOI 10.1007/s10856-011-4542-x

Abstract

Being able to control the behaviour of osteoblast-like cells on a surface may provide a genuine insight into the material surface characteristics and help in creating a successful coating/cell interface. The possibility of creating a micro-environment that can induce proliferation, differentiation and mineralisation of bone cells in vitro, by successfully combining both chemistry and topography of a micro-fabricated substrate is an area that requires a multidisciplinary approach. Utilising sputter deposition, a process that lends itself to high processability, in conjunction with photolithography allowing for the creation of highly repeatable etched surfaces, we aim to provide a successful combination of chemistry and topography. Correlating the substrate conditions with resultant osteoblast biological function and activity can ultimately be used with a view to modulating the behavior of osteoblast-like cells in vitro.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:21034
Deposited By:Dr George Burke
Deposited On:03 Dec 2012 10:15
Last Modified:03 Dec 2012 10:15

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