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McClean, Stephen (2011) Investigation of Animal Venoms and Toxins. In: Methods in Animal Proteomics. Wiley-Blackwell, pp. 211-241. ISBN 978-0813817910 [Book section]
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URL: http://dx.doi.org/10.1002/9780470960660.ch9
DOI: 10.1002/9780470960660.ch9
Abstract
This chapter contains sections titled:* Introduction* Natural Bioresources* Pharmaceutical Success Stories* The Methods in Toxin Sequencing* Reducing Complexity by Chromatography* Bioassay Considerations* Classical Edman* Overview of MS Methods for Chemical Prospecting* Soft Ionization Methods* Common Mass Analyzers for Peptide Analysis* Information Obtained from Different MS Systems* Cloning Studies* New Developments and Future Trends* Conclusions* Other Sources of Information* References
| Item Type: | Book section |
|---|---|
| Keywords: | animal venom and toxin investigation - mass spectrometric technologies in structural characterization of peptides, role of matrix-assisted laser desorption/ionization-time-of-flight (MALDI - TOF) analysis - tandem mass spectrometry (MS/MS) sequencing combined with database searching, Escoubas and colleagues, and therapeutic potential of peptides - from arachnids, pharmaceutical success stories - Cytolex (Pexiganan), in foot ulcer treatment, in diabetic patients, toxin sequencing methods - first step in analytical process, venom from specimens, novel approach by Tyler's group in Australia - transdermal electrical stimulation for skin secretion extraction, reducing complexity by chromatography - skin secretions, by separation technologies, MS methods for chemical prospecting - standard tool in laboratories, MS/MS Methods MS/MS sequencing - and database searching, identifying previously characterized sequences, method of corroborating sequence calls, needed - de novo sequencing, and Edman degradation or by cDNA cloning studies |
| Faculties and Schools: | Faculty of Life and Health Sciences Faculty of Life and Health Sciences > School of Biomedical Sciences |
| Research Institutes and Groups: | Biomedical Sciences Research Institute Biomedical Sciences Research Institute > Pharmaceutical Science and Practice |
| ID Code: | 20190 |
| Deposited By: | Dr Stephen McClean |
| Deposited On: | 04 Oct 2011 11:16 |
| Last Modified: | 04 Oct 2011 11:16 |
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