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Ratiometric fluorescent detection of Cu(II) in semi-aqueous solution using a two-fluorophore approach

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Singh, Narinder, Kaur, Navneet, Callan, Bridgeen and Callan, John (2010) Ratiometric fluorescent detection of Cu(II) in semi-aqueous solution using a two-fluorophore approach. TETRAHEDRON LETTERS, 51 (26). pp. 3385-3387. [Journal article]

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DOI: 10.1016/j.tetlet.2010.04.099


Schiff base sensor 1, containing naphthalene and naphthalimide fluorophores with separate and distinct emission wavelengths, showed good selectivity for Cu(II) over other tested physiological and environmentally important cations through changes in its fluorescence spectra in THF/H(2)O (9:1) HEPES buffered solution. By taking the ratiometric change of the emissions at 435 nm (naphthalene-Schiff base) and 510 nm (naphthalimide) good linearity was observed in the 0-10 mu M range. The enhancement of the 435 nm emission upon binding Cu(2+) was attributed to a prevention of the rapid C=N isomerisation that otherwise leads to non-radiative decay, while the quenching of the naphthalimide emission was attributed to electron transfer between the excited naphthalimide fluorophore and the redox active Cu(2+). (C) 2010 Elsevier Ltd. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:19933
Deposited By:Professor John Callan
Deposited On:13 Sep 2011 14:56
Last Modified:19 Nov 2012 15:16

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