Chen, TB, Orr, DF, Bjourson, AJ, McClean, Stephen, O'Rourke, M, Hirst, DG, Rao, PF and Shaw, C (2002) Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis). PEPTIDES, 23 (9). pp. 1547-1555. [Journal article]
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Bradykinin and (Thr(6))-bradykinin have been identified in the defensive skin secretion of the fire-bellied toad, Bombina orientalis. The homologous cDNAs for both peptides were cloned from a skin library using a 3'- and 5'-RACE strategy. Kininogen-1 (BOK-1) contained an open-reading frame of 167 amino acid residues encoding four repeats of bradykinin, and kininogen-2 (BOK-2) contained an open-reading frame of 161 amino acid residues encoding two repeats of (Thr(6))-bradykinin. Alignment of both precursor nucleotide and amino acid sequences revealed a high degree of structural similarity. These amphibian skin kininogens/preprobradykinins are not biologically analogous to mammalian kininogens. (C) 2002 Elsevier Science Inc. All rights reserved.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
|Deposited By:||Mrs Caroline Adams|
|Deposited On:||30 Nov 2009 09:37|
|Last Modified:||15 Jun 2011 10:52|
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