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Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis)

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Chen, TB, Orr, DF, Bjourson, AJ, McClean, Stephen, O'Rourke, M, Hirst, DG, Rao, PF and Shaw, C (2002) Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis). PEPTIDES, 23 (9). pp. 1547-1555. [Journal article]

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URL: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0M-46NXNCX-2&_user=126978&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000010438&_version=1&_urlVersion=0&_userid=126978&md5=7320d53ff1bc5be630f96c603dd52786

Abstract

Bradykinin and (Thr(6))-bradykinin have been identified in the defensive skin secretion of the fire-bellied toad, Bombina orientalis. The homologous cDNAs for both peptides were cloned from a skin library using a 3'- and 5'-RACE strategy. Kininogen-1 (BOK-1) contained an open-reading frame of 167 amino acid residues encoding four repeats of bradykinin, and kininogen-2 (BOK-2) contained an open-reading frame of 161 amino acid residues encoding two repeats of (Thr(6))-bradykinin. Alignment of both precursor nucleotide and amino acid sequences revealed a high degree of structural similarity. These amphibian skin kininogens/preprobradykinins are not biologically analogous to mammalian kininogens. (C) 2002 Elsevier Science Inc. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
Biomedical Sciences Research Institute > Stratified Medicine
ID Code:1936
Deposited By:Mrs Caroline Adams
Deposited On:30 Nov 2009 09:37
Last Modified:14 Oct 2013 15:47

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