Chen, TB, Bjourson, AJ, McClean, Stephen, Orr, DF, O'Kane, EJ, Rao, PF and Shaw, C (2003) Cloning of maximakinin precursor cDNAs from Chinese toad, Bombina maxima, venom. PEPTIDES, 24 (6). pp. 853-861. [Journal article]
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Using a novel technique that we have developed for cloning of amphibian skin secretion peptide cDNAs from lyophilized samples, we report here that maximakinin (DLPKINRKGP-bradykinin) is encoded by two different cDNAs, named BMK-1 and BMK-2, containing either four tandem repeat sequences or a single copy. The open reading frames of both precursor cDNAs were found to be 152 and 116 amino acid residues, respectively. These data provide evidence that the structural diversity of peptides in amphibian skin secretions arising front molecular evolutionary events, can be mediated by parallel diversity in encoding mRNAs that in itself may reflect serial gene duplications. (C) 2003 Elsevier Inc. All rights reserved.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
Biomedical Sciences Research Institute > Stratified Medicine
|Deposited By:||Mrs Caroline Adams|
|Deposited On:||30 Nov 2009 09:27|
|Last Modified:||14 Oct 2013 15:29|
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