McClean, Conor and Davison, Gareth (2011) Gastrointestinal transit, post-prandial lipaemia and satiety following 3 days high-fat diet in men. European Journal of Clinical Nutrition, 65 (2). pp. 240-246. [Journal article]
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BACKGROUND/OBJECTIVES: High-fat (HF) diets of 2 weeks have been shown to accelerate gastric emptying (GE). To date, no studies have shown any alteration in GE following shorter HF diets. The aim of this study was to assess if an HF, high-energy diet of 3 days can adapt gastrointestinal (GI) transit, blood lipids and satiety.SUBJECTS/METHODS: Eleven male volunteers participated in a study consisting of three, 3-day interventions each separated by a test day. During the first intervention, volunteers recorded their diet. In the second and third interventions, volunteers repeated their food diary plus either a low-fat yogurt or HF yogurt supplement in randomized order. Test days involved measurement of GE using the (13)C octanoic-acid breath-test, mouth-to-caecum transit time (MCTT) using the inulin H(2) breath test and satiety using visual analogue scales. Blood samples for measurement of lipaemia were taken using a venous cannula.RESULTS: MCTT was different between the three test days (P=0.038), with the shortest MCTT following the HF intervention. GE was shortest following the HF intervention. There were no differences in satiety between the interventions. The HF intervention reduced triglycerides, total cholesterol and low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol.CONCLUSION: This study shows that changes in GI transit owing to an HF diet can occur in a time period as short as 3 days.
|Item Type:||Journal article|
|Keywords:||gastric emptying; lipaemia; mouth-to-caecum transit time; satiety|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Sport
|Research Institutes and Groups:||Sport and Exercise Sciences Research Institute|
Sport and Exercise Sciences Research Institute > Centre for Physical Activity and Health
|Deposited By:||Dr Conor McClean|
|Deposited On:||07 Jun 2011 09:14|
|Last Modified:||25 Sep 2013 12:51|
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