Hogan, Michael J., Carolan, Leigh, Roche, Richard A. P., Dockree, Paul M., Kaiser, Jochen, Bunting, Brendan, Robertson, Ian H. and Lawlor, Brian A. (2006) Electrophysiological and information processing variability predicts memory decrements associated with normal age-related cognitive decline and Alzheimer's disease (AD). BRAIN RESEARCH, 1119 . pp. 215-226. [Journal article]
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Recent theoretical models of cognitive aging have implicated increased intra-individual variability as a critical marker of decline. The current study examined electrophysiological and information processing variability and memory performance in normal younger and older controls, and older adults with Alzheimer's disease (AD). It was hypothesized that higher levels of variability would be indicative of age-related and disease-related memory deficits. Results indicated both implicit and explicit memory deficits associated with AD. Consistent with previous research, behavioral speed and variability emerged as sensitive to age- and disease-related change. Amplitude variability of P3 event-related potentials was a unique component of electrophysiological activity and accounted for significant variance in reaction time (RT) mean and RT standard deviation, which in turn accounted for significant variance in memory function. Results are discussed in light of theoretical and applied issues in the field of cognitive aging. (c) 2006 Elsevier B.V. All rights reserved.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Psychology
|Research Institutes and Groups:||Psychology Research Institute|
Psychology Research Institute > Health Psychology
|Deposited By:||Mrs Fiona Harkin|
|Deposited On:||14 Dec 2009 14:30|
|Last Modified:||12 Mar 2012 16:54|
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