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Geometric Formalism for DNA Quadruplex F olding

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Webba da Silva, Mateus (2007) Geometric Formalism for DNA Quadruplex F olding. Chem. Eur. J., 13 . [Journal article]

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DOI: 10.1002/chem.200701255

Abstract

Understanding the control of self-assemblyand stereochemical properties of DNA higher orderACHTUNGTRENUNGarchitectural folds is of fundamental importance in biologyas well as biochemical technological applications.Guanine-rich DNA sequences can form tetrahelicalACHTUNGTRENUNGarchitectures termed quadruplexes. A formalism is presenteddescribing the interdependency of a set of structuraldescriptors as a geometric basis for folding of unimolecularquadruplex topologies. It represents a standardfor interpretation of structural characteristics ofquadruplexes, and is comprehensive in explicitly harmonizingthe results of published literature with a unifiedlanguage. The formalism is a fundamental step towardsprediction of unimolecular quadruplex folding topologiesfrom primary sequence.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Transcriptional Regulation & Epigenetics
ID Code:18293
Deposited By:Dr Mateus Webba da Silva
Deposited On:03 May 2011 11:16
Last Modified:04 Dec 2012 14:23

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