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Rapid Stoichiometric Analysis of G-Quadruplexes in Solution

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Groves, P and Webba da Silva, Mateus (2010) Rapid Stoichiometric Analysis of G-Quadruplexes in Solution. Chem. Eur. J., 16 . pp. 6451-6453. [Journal article]

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DOI: DOI: 10.1002/chem.200901248

Abstract

Guanine-rich sequences of nucleic acids may fold into secondarystructural folds called quadruplex architectures.These architectures are a rapidly growing theme of interestwith promising repercussions in our understanding of biologyand practical applications in medical fields, materialsscience, and biotechnology. Currently, there is thus interestin determining both topology and their atomic detail 3Dstructures. The establishment of solution conditions suitablefor structural studies of G-quadruplex architectures requiresthe determination of the level of oligomerization (stoichiometry)of DNA strands. Various analytical techniques arecurrently applied for the routine assessment of the stoichiometrythat generally include conditions not representativeof the environment in which the structural studies are performed.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Transcriptional Regulation & Epigenetics
ID Code:18289
Deposited By:Dr Mateus Webba da Silva
Deposited On:03 May 2011 11:27
Last Modified:04 Dec 2012 14:21

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