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Deriving a Reduced Lead System from the 80-Lead Body Surface Map in the Electrocardiographic Determination of Acute Myocardial Infarction.

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Scott, PJ, Stevenson, M, Navarro, M, Hamilton, A, Bennett, JR, Owens, C, Manoharan, G, Escalona, OJ, Anderson, JMCC and Adgey, AAJ (2008) Deriving a Reduced Lead System from the 80-Lead Body Surface Map in the Electrocardiographic Determination of Acute Myocardial Infarction. In: UNSPECIFIED. Elsevier . Vol 41 [Conference contribution]

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Background: Body surface mapping (BSM) involves the application of extra electrodes or “nonstandard lead sets” over a larger area of the thorax than the routine 12-lead electrocardiogram (ECG). The number of electrodes can range from15 tomore than 250, and the optimum number and placement of leads is a major topic of research.We used a novel retrospective approach, analyzing the records from patients admitted to our center with acute ischemic-type chest pain, to determine optimum lead number and placement.Methods: We analyzed 576 patients with acute myocardial infarction (MI) (242 anterior, 173 inferior, 69 lateral, 69 posterior, and 23 right ventricular; peak cardiac troponin T N 0.09 nmol/L) and 279 controls (normal ECG and cardiac markers). Infarct location was verified by 2 cardiologists not involved in the study. Initially, an 80-lead (64 anterior, 16 posterior) BSM(Prime ECG) was recorded on all patients prior to revascularization. A combined method of analysis for a reduced lead set was used—analysis of variance (ANOVA)determined which leads had the greatest mean ST elevation (ST0 [mm]), logistic regression analysis of the ST0 ranked each lead in terms of MI diagnosis, and a computer algorithm determined which leads in combination produced the greatest sensitivity and specificity for MI diagnosis.Results: Thus, a 30-lead set (20 anterior, 10 posterior) was derived from the combined method of analysis. The sensitivity and specificity of the 30-lead set forMIwas 84% and 97%, respectively, compared with the 80-leadBSMof 91% and 93%. Receiver operating characteristic (ROC) c statistic for the 30 lead set was 0.825 (95% confidence interval, 0.797-0.852), which was within the 95% confidence intervals for the 80 lead ROC c statistic of 0.850 (0.824-0.875). The data set was split equally into training and validation set. The training set ROC c statistic for the 30-lead set was 0.860 (0.825-0.896) and 0.908 (0.881-0.935) for the 80-lead set. The validation set ROC c statistic was 0.821 (0.782-0.860) forthe 30-lead set and 0.782 (0.739-0.825) for the 80-lead set.Conclusion: Using the ROC c statistic, we showed that the 30-lead BSM was noninferior to the 80-lead model.

Item Type:Conference contribution (UNSPECIFIED)
Keywords:Electrocardiography, accute myocardial infarction, BSPM, Cardiac mapping, 28-lead harness, chest pain, esrly diagnosis of AMI
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:17923
Deposited By:Professor Omar Escalona
Deposited On:05 Apr 2011 08:46
Last Modified:17 Oct 2012 14:56

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