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Enthalpimetric measurements of the strengths of immobilized cholinesterase inhibitors

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Trewhella, M, Owusu, RK and Finch, Arthur (1985) Enthalpimetric measurements of the strengths of immobilized cholinesterase inhibitors. Thermochimica Acta, 90 (1). pp. 305-312. [Journal article]

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URL: http://dx.doi.org/10.1016/0040-6031(85)87108-2

DOI: doi:10.1016/0040-6031(85)87108-2

Abstract

A rapid, reproducible method is described for the enthalpimetric determination of the relative inhibitory strengths of a series of 29 reversible acetylcholinesterase and butyrylcholinesterase inhibitors. The technique continuously monitors the activity of glass-immobilized cholinesterases, which can be rapidly and quantitatively reactivated simply by removal of the inhibitor. Complete inhibition curves are presented for some of the most potent inhibitors. For the strongest inhibitors, it is possible to detect amounts as low 5×10−9 mol.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:17618
Deposited By:Dr Richard Owusu-Apenten
Deposited On:01 Apr 2011 10:02
Last Modified:01 Apr 2011 10:02

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