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Electrochemical Monitoring of Nucleic Acid Hybridization by Single-Use Graphene Oxide-Based Sensor

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Muti, M, Sharma, S, Erdem, A and Papakonstantinou, P (2011) Electrochemical Monitoring of Nucleic Acid Hybridization by Single-Use Graphene Oxide-Based Sensor. Electroanalysis, 23 (1). pp. 272-279. [Journal article]

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URL: http://onlinelibrary.wiley.com/doi/10.1002/elan.201000425/abstract

DOI: 10.1002/elan.201000425

Abstract

In this paper, the application of a Graphene oxide (GRPox) integrated on single-use pencil graphite electrode (PGE) for the enhanced monitoring of nucleic acids and for the sensitive and selective detection of the label free DNA hybridization related to Hepatitis B virus (HBV) sequences is described. Electrochemical behaviors of GRPox modified PGEs were firstly investigated using electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). The sequence selective DNA hybridization was determined voltammetrically in the case of hybridization between amino linked probe and its complementary (target), or, noncomplementary (NC), or target/mismatch (MM) mixtures (1 :1).

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:16847
Deposited By:Professor Pagona Papakonstantinou
Deposited On:18 Jan 2011 11:08
Last Modified:20 Jan 2011 14:52

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