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CONDITIONED SUPPRESSION AND THE EFFECTS OF PENTOBARBITAL WITH PICROTOXIN, FLUMAZENIL, AND R05-3663

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Leslie, Julian, TOAL, L and SHEPHARD, RA (1995) CONDITIONED SUPPRESSION AND THE EFFECTS OF PENTOBARBITAL WITH PICROTOXIN, FLUMAZENIL, AND R05-3663. PSYCHOLOGICAL RECORD, 45 (2). pp. 299-307. [Journal article]

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Abstract

In two experiments, rats trained to lever press for food were maintained under a conditioned suppression procedure and then given an acute regime of drug administration involving pentobarbital (10 mg/kg). In both experiments, pentobarbital reduced conditioned suppression. In the first experiment (4 rats), this effect was increased by the combination of the specific benzodiazepine antagonist flumazenil (10 mg/kg) with pentobarbital but unaffected by the combination of picrotoxin (1.5 mg/kg) with pentobarbital. In the second experiment (3 rats), this effect was attenuated when picrotoxin (2.0 mg/kg) or Ro5-3663 (5.0 mg/kg) were also administered. These findings add to the data on the effects of anxiolytics and related compounds on conditioned suppression, they provide more information on the possible nature of the GABA/benzodiazepine receptor complex and suggest that flumazenil can have anxiolytic as well as anxiogenic effects.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute
Psychology Research Institute > Behavioural Neuroscience & Behavioural Analysis
ID Code:1670
Deposited By:Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:35
Last Modified:13 Mar 2012 16:33

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