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An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Doherty, Bernadette, Rodriguez, Virginia, Leslie, Julian, McClean, Stephen and Smyth, W. Franklin (2007) An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21 (13). pp. 2031-2038. [Journal article]

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DOI: 10.1002/rcm.3060

Abstract

A tandem mass spectrometric investigation of the collision-induced dissociation of five commonly prescribed psychoactive pharmaceuticals, risperidone, sertraline, paroxetine, trimipramine, and mirtazapine, and their metabolites has been carried out. Quadrupole ion trap mass spectrometry was employed to generate tandem mass spectrometric (MS/MS) data of the compounds under investigation and structural assignments of product ions were supported by quadrupole time-of-flight mass spectrometry. These fragmentation studies were then utilised in the development of a liquid chromatographic method to identify the drugs and their metabolites in human hair and saliva samples, thus providing relevant profiling information. Copyright (C) 2007 John Wiley & Sons, Ltd.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Biomedical Sciences Research Institute
Psychology Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
Psychology Research Institute > Behavioural Neuroscience & Behavioural Analysis
ID Code:1644
Deposited By:Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:30
Last Modified:13 Mar 2012 16:33

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