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ARC POMC mRNA and PVN alpha-MSH are lower in obese relative to lean Zucker rats

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Kim, Eun-Mee, O'Hare, E, Grace, MK, Welch, CC, Billington, CJ and Levine, AS (2000) ARC POMC mRNA and PVN alpha-MSH are lower in obese relative to lean Zucker rats. BRAIN RESEARCH, 862 (1-2). pp. 11-16. [Journal article]

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Abstract

Effects of obesity on gene expression for opioid peptides and neuropeptide-Y (NPY) in the arcuate nucleus (ARC), and on opioid peptides and alpha-melanocyte stimulating hormone (alpha-MSH) in the paraventricular nucleus (PVN) were examined in obese Zucker rats (18 weeks old). Obese Zucker rats are insulin-resistant, diabetic and hyperleptinemic as indicated by high serum glucose, insulin and leptin levels. ARC proOpiomelanocortin (POMC) mRNA levels were significantly lower in the obese relative to lean Zucker rats and ARC proNeuropeptide Y (proNPY) mRNA levels were higher (P<0.05). There were no differences in proDynorphin and proEnkephalin mRNA levels in the ARC (P > 0.05). Obese Zucker rats had lower alpha-MSH and dynorphin A(1-17) peptide levels in the paraventricular nucleus (PVN) (P < 0.05), but did not have lower PVN beta-endorphin peptide levels (P > 0.05). The decrease in POMC in the ARC and decrease in alpha-MSH in the PVN seen in the obese Zucker rat in the present study suggest that reduced activity of the melanocortin system in the ARC to PVN pathway may contribute to the related hyperphagia. Reduced activity of the melanocortin system in the ARC to PVN pathway may be due to a disturbance of leptin signaling coupling to POMC. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute
Psychology Research Institute > Behavioural Neuroscience & Behavioural Analysis
ID Code:1642
Deposited By:Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:29
Last Modified:13 Mar 2012 16:34

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