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Identification of central sites involved in butorphanol-induced feeding in rats

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Kim, Eun-Mee, Shi, Q, Olszewski, PK, Grace, MK, O'Hare, E, Billington, CJ and Levine, AS (2001) Identification of central sites involved in butorphanol-induced feeding in rats. BRAIN RESEARCH, 907 (1-2). pp. 125-129. [Journal article]

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Abstract

Butorphanol (BT), a mixed kappa- and mu -opioid receptor agonist, induces vigorous food intake in rats. Peripheral injection of BT seems to increase food intake more effectively than intracerebroventricular administration. To further elucidate the nature of BT's influence on consummatory behavior. we examined which feeding-related brain areas exhibit increased c-Fos immunoreactivity (IR) following subcutaneous injection of 4 mg/kg body weight BT, a dose known to induce a maximal orexigenic response. We also evaluated whether direct administration of BT into the forebrain regions activated by peripheral BT injection affects food intake. Peripheral BT administration induced c-Fos-IR in the hypothalamic paraventricular nucleus (PVN), central nucleus of the amygdala (CeA), and nucleus of the solitary tract (NTS). However, 0.1-30 mug BT infused into the CeA, failed mo increase food intake 1, 2, and 4 h after injection. Only the highest dose of BT (30 mug) injected into the PVN: increased feeding. These results suggest that the PVN, CeA, and NTS mediate the effects of peripherally-injected BT. The PVN or CeA are probably not the main target sites of immediate BT action. Published by Elsevier Science B.V.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute
Psychology Research Institute > Behavioural Neuroscience & Behavioural Analysis
ID Code:1641
Deposited By:Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:29
Last Modified:13 Mar 2012 16:34

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