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Injection of alpha-MSH, but not beta-endorphin, into the PVN decreases POMC gene expression in the ARC

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Kim, Eun-Mee, Grace, MK, O'Hare, E, Billington, CJ and Levine, AS (2002) Injection of alpha-MSH, but not beta-endorphin, into the PVN decreases POMC gene expression in the ARC. NEUROREPORT, 13 (4). pp. 497-500. [Journal article]

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Abstract

beta-Endorphin (beta-END) and alpha-melanocyte stimulating hormone (alpha-MSH), neuropeptides derived from proopiomelanocortin (POMC), have opposite effects on eating behavior. We injected rats with alpha-MSH (0.6 nmol) or beta-END (1 nmol) into the PVN (three times in a 26 h period). These doses of alpha-MSH and beta-END decreased and increased feeding respectively. Following alpha-MSH administration into the PVN, m RNA levels of POMC decreased by 17%, whereas there was no significant change in gene expression of either proDynorphin or proEnkephalin. PVN injection of beta-END failed to alter gene expression of POMC, proDynorphin or proEnkephalin. These data suggest that a feedback pathway exists between the PVN and ARC for alpha-MSH and POMC, but not for beta-END and POMC.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute
Psychology Research Institute > Behavioural Neuroscience & Behavioural Analysis
ID Code:1640
Deposited By:Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:29
Last Modified:13 Mar 2012 16:34

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