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Parenteral antioxidant treatment preserves temporal discrimination following intrahippocampal aggregated A beta((1-42)) injections

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

McDaid, DG, Kim, Eun-Mee, Reid, RE, Leslie, Julian, Cleary, J and O'Hare, E (2005) Parenteral antioxidant treatment preserves temporal discrimination following intrahippocampal aggregated A beta((1-42)) injections. BEHAVIOURAL PHARMACOLOGY, 16 (4). pp. 237-242. [Journal article]

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Abstract

There is evidence that oxidative stress may play a role in the neuropathology of Alzheimer's disease (AD). This study used an aggregated beta-amyloid (A beta) injection model of AD in the rat, and a recycling conjunctive schedule of food reinforcement to examine the effects of bilateral intrahippocampal injections of aggregated A beta((1-42)) (5.0 mu l/side) on temporal discrimination, and the efficacy of the antioxidant alpha-tocopherol (150 mg/kg daily p.o.) in alleviating these effects. The results indicated that bilateral intrahippocampal injections of aggregated A beta((1-42)) detrimentally affected temporal discrimination from five-day block 31-35 post-injections until the end of the study (90 days post-injections). Daily treatment with alpha-tocopherol improved temporal discrimination under the recycling conjunctive schedule following aggregated A beta((1-42)) injections from the five-day block 61-65 days until the end of the study.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute
Psychology Research Institute > Behavioural Neuroscience & Behavioural Analysis
ID Code:1633
Deposited By:Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:28
Last Modified:13 Mar 2012 16:33

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