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Chronic intracerebroventricular infusion of lipopolysaccharide: effects of ibuprofen treatment and behavioural and histopathological correlates

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Richardson, RL, Kim, Eun-Mee, Gardiner, T and O'Hare, E (2005) Chronic intracerebroventricular infusion of lipopolysaccharide: effects of ibuprofen treatment and behavioural and histopathological correlates. BEHAVIOURAL PHARMACOLOGY, 16 (7). pp. 531-541. [Journal article]

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Abstract

Twenty male Wistar rats were trained under an alternating-lever cyclic-ratio (ALCR) schedule of food reinforcement. When responding showed no trends, each subject was subcutaneously implanted with an Alzet osmotic mini-pump, connected to a chronic indwelling cannula extending into the lateral ventricle of the brain. The mini-pumps were primed to infuse 0.25 mu l lipopolysaccharide (LPS) (1.0 mu g/0.25ml) or 0.25 mu l artificial cerebrospinal fluid (aCSF) per hour and were implanted for 28 days. LIDS infusion produced behavioural deficits which chronic ibuprofen treatment (40 mg/kg every 12 h) alleviated. Infusion of LIDS induced R1282-positive amyloid deposits, and activation of microglia and astrocytes. lbuprofen treatment reduced the numbers of activated microglia, and withdrawal of ibuprofen resulted in an increase in activated microglia; however, ibuprofen treatment had no effect on numbers of activated astrocytes in the LPS-infused subjects.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute
Psychology Research Institute > Behavioural Neuroscience & Behavioural Analysis
ID Code:1632
Deposited By:Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:28
Last Modified:13 Mar 2012 16:34

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