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Oligomers of the amyloid-beta protein disrupt working memory: Confirmation with two behavioral procedures

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Poling, Alan, Morgan-Paisley, Kineta, Panos, John J., Kim, Eun-Mee, O'Hare, Eugene, Cleary, James P., Lesne, Sylvain, Ashe, Karen H., Porritt, Matthew and Baker, Lisa E. (2008) Oligomers of the amyloid-beta protein disrupt working memory: Confirmation with two behavioral procedures. BEHAVIOURAL BRAIN RESEARCH, 193 (2). pp. 230-234. [Journal article]

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DOI: 10.1016/j.bbr.2008.06.001

Abstract

Converging lines of evidence suggest that oligomers of amyloid-P play a role in the cognitive impairment characteristic of Alzheimer's disease, but only three studies have provided experimental evidence of such impairment. To provide additional information about the effects of these oligomers on memory, the present study examined the memory of groups of rats exposed to ICV injections of the culture media (CM) of Chinese Hamster Ovary cells that were (7PA2) and were not (CHO-) transfected with a human mutation of amyloid precursor protein that appears to cause early-onset Alzheimer's disease. The 7PA2 CM, which contained concentrations of soluble amyloid-P oligomers physiologically relevant to those found in human brain, significantly disrupted working memory in rats tested in a radial-arm maze. In contrast, CHO- CM, which did not contain such oligomers, had no effect on memory. The disruptive effects of 7PA2-derived amyloid-beta oligomers, evident 2 h after exposure, disappeared within a day. These findings are compared to results from 7PA2 CM tested under a complex procedure thought to measure aspects of executive function. The results confirm the disruptive effects of low-n amyloid-beta oligomers and extend them to a well-established rat model of memory. (C) 2008 Elsevier B.V. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute
Psychology Research Institute > Behavioural Neuroscience & Behavioural Analysis
ID Code:1628
Deposited By:Mrs Fiona Harkin
Deposited On:23 Dec 2009 09:27
Last Modified:13 Mar 2012 16:34

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