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Homocysteine and related B-vitamin status in coeliac disease: Effects of gluten exclusion and histological recovery

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Dickey, William, Ward, M., Whittle, Claire R, Kelly, Mary T, Pentieva, Kristina, Horigan, Geraldine, Patton, Sharon and McNulty, H (2008) Homocysteine and related B-vitamin status in coeliac disease: Effects of gluten exclusion and histological recovery. Scandinavian Journal of Gastroenterology, 43 (6). pp. 682-688. [Journal article]

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DOI: 10.1080/00365520701881118

Abstract

Objective. Hyperhomocysteinaemia is considered to be a risk factor for cardiovascular disease (particularly stroke) and has been implicated in recurrent miscarriage and osteoporotic fracture, recognized manifestations of coeliac disease (CD). The objective of this study was to compare plasma homocysteine levels and biomarker status of metabolically related B vitamins (folate, vitamin B-12, B-6 and riboflavin) in treated and untreated CD patients and healthy controls. Material and methods. CD patients attending a clinic for either initial or follow-up biopsy (at least 12 months after commencing a gluten-free diet) were categorized into three groups: 1) newly diagnosed (untreated; n=35); 2) persistent villous atrophy (VA) at follow-up (n=24) or 3) recovered VA at follow-up (n=41). Blood samples were analysed for plasma homocysteine, serum and red cell folate and serum vitamin B-12 levels, and for plasma pyridoxal 5-phosphate (PLP, vitamin B-6) and riboflavin (vitamin B-2) status. Results. Homocysteine concentrations were significantly higher (p=0.05) and red cell and serum folate significantly lower (p<0.001) in untreated patients compared with controls, while all three reached normal levels in recovered VA patients. Although untreated and persistent VA patients tended to have lower B-12 levels, these did not reach significance. There was no evidence of compromised B-6 or riboflavin status, even in untreated CD patients. Homocysteine concentrations were inversely associated with both serum (r=-0.421; p<0.001) and red cell (r=-0.459; p<0.001) folate and with serum vitamin B-12 (r=-0.353; p=0.001). Conclusions. Gluten exclusion in CD improves folate status and normalizes homocysteine concentrations. Reducing the risk of homocysteine-related disease may be another reason for aggressive diagnosis and treatment of CD.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:15470
Deposited By:Mrs Alison Deehan
Deposited On:13 Sep 2010 15:41
Last Modified:01 Nov 2011 12:52

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