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Selective determination of thiols: a novel electroanalytical approach

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Lawrence, NS, Davis, J, Jiang, L, Jones, TGJ, Davis, SN and Compton, RG (2000) Selective determination of thiols: a novel electroanalytical approach. ANALYST, 125 (4). pp. 661-663. [Journal article]

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Abstract

The two electron electro-oxidation of N,N-dimethylphenylene-1,4-diamine and related compounds in aqueous solution leads to the formation of the corresponding 1,4-diimine which reacts with a range of thiol compounds. The resulting ring substituted (R-S-) diamine is further oxidised leading to an increase in the oxidative current which is proportional to the concentration of the thiol species. The electrode responses were found to be selective towards species including cysteine and homocysteine containing sulfhydryl groups (RSH) with no reaction observed with either methionine (CH3SCH2CH(COOH)NH2) or cystine (cystein-S-S-cysteine). The potential required to oxidise the ring substituted diamine is found to be dependent upon the nature of the thiol constituent and may allow some scope for speciation studies.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:14390
Deposited By:Professor James Davis
Deposited On:01 Jul 2010 10:00
Last Modified:18 Aug 2011 11:18

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