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Sonoelectrochemically enhanced determination of 5-aminosalicylic acid

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Beckett, EL, Lawrence, NS, Evans, RG, Davis, J and Compton, RG (2001) Sonoelectrochemically enhanced determination of 5-aminosalicylic acid. TALANTA, 54 (5). pp. 871-877. [Journal article]

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The electrochemical detection of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) has been evaluated through the application of linear sweep, square wave and sonolinear sweep voltammetry. The introduction of ultrasound is shown to significantly enhance the oxidation signal intensity thereby enabling the detection of low concentrations with the linear range (1-57 muM) adequate for assessing free drug within physiological samples. interference from ascorbic acid can be effectively negated through the introduction of cupric ion without any appreciable cost to the voltammetric response to 5-ASA. The efficacy of employing sonolinear sweep voltammetry to the determination of this compound within a compositionally complex tissue culture medium has been assessed with the recovery of 5 muM 5-ASA found to be 102% (RSD = 5%, N = 3). (C) 2001 Elsevier Science B.V. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:14375
Deposited By:Professor James Davis
Deposited On:01 Jul 2010 09:53
Last Modified:18 Aug 2011 11:18

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