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Electrochemically initiated 1,4 additions: a versatile route to the determination of thiols

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

White, PC, Lawrence, NS, Davis, J and Compton, RG (2001) Electrochemically initiated 1,4 additions: a versatile route to the determination of thiols. ANALYTICA CHIMICA ACTA, 447 (1-2). pp. 1-10. [Journal article]

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Abstract

The electrochemical generation of quinoid intermediates and their subsequent reaction with sulphydryl thiols (RSH) have been investigated as a method by which the latter can be quantified. Nucleophilic addition of the thiol species to the electrogenerated quinoid structure leads to the production of a chemically reduced adduct whose subsequent re-oxidation at the electrode leads to an amplification of the oxidative current. This can be correlated to the concentration of thiol present within the medium. The influence of indicator composition on the nature of the analytical response has been assessed through examining the electrochemical properties of 15 derivatives and the validity of the proposed reaction pathway corroborated by comparison of the voltammetric response with computer simulations. Interference by other electroactive species (ascorbate, urate, tyrosine) and other physiological constituents (cystine, lysine) has also been assessed. (C) 2001 Elsevier Science B.V. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:14369
Deposited By:Professor James Davis
Deposited On:01 Jul 2010 09:49
Last Modified:18 Aug 2011 11:19

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