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Nitration: A selective electrochemical label for the determination of activated aromatics

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Beckett, EL, Lawrence, NS, Davis, J and Compton, RG (2002) Nitration: A selective electrochemical label for the determination of activated aromatics. ANALYTICAL LETTERS, 35 (2). pp. 339-353. [Journal article]

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Abstract

The use of nitration as a method of derivatising activated aromatic species such that the resulting nitro functionality can serve as an electroactive label has been examined. The nitration reaction is conducted so as to minimise oxidative degradation of the target analyte. The nature of the resulting assay protocol has been characterised using phenol as a model analyte and the products resulting from the assay procedure and the subsequent electrochemical investigations identified. The applicability of the protocol was evaluated through the determination of tyrosine and the selectivity of the approach assessed through the recovery of the amino acid within a compositionally complex tissue culture medium. Reduction of the nitro functionality is shown to provide a versatile label through which the parent analyte can be reliably quantified with a high degree of selectivity.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:14365
Deposited By:Professor James Davis
Deposited On:01 Jul 2010 09:48
Last Modified:18 Aug 2011 11:19

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