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A clinical assessment of direct electrochemical urate measurements

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Dutt, JSN, Livingstone, C, Cardosi, MF, Wilkins, SJ and Davis, J (2006) A clinical assessment of direct electrochemical urate measurements. TALANTA, 68 (5). pp. 1463-1468. [Journal article]

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DOI: 10.1016/j.talanta.2005.08.020

Abstract

The response characteristics of various carbon substrates towards the direct oxidative measurement of urate and other key purine biomarkers have been compared. A novel carbon fibre laminate assembly has been proposed as an alternative substrate for the preparation of disposable sensing strips. The fabrication method is generic and readily transferable to a number of sensor applications. Its performance in the determination of urate within biofluids (serum and plasma) has been critically assessed. An inter-Laboratory pilot study demonstrated the bioanalytical efficacy of the approach with the responses validated through comparison with the standard colorimetric (uricase/peroxidase) assay. (c) 2005 Elsevier B.V. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:14333
Deposited By:Professor James Davis
Deposited On:01 Jul 2010 09:22
Last Modified:18 Aug 2011 11:19

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