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Metabolic mimics: Thiol responsive drug release

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Solsona, IA, Smith, RB, Livingstone, C and Davis, J (2006) Metabolic mimics: Thiol responsive drug release. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 302 (2). pp. 698-701. [Journal article]

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DOI: 10.1016/j.jcis.2006.06.042

Abstract

A new approach to the design of selective release interfaces is assessed in which a hydrophobic component is functionalised with a receptor reactive toward reduced thiol peptides-principally glutathione. The assembly has been characterised using electrochemical techniques and its ability to form a coherent, water insoluble coating is demonstrated. The subsequent reaction with glutathione creates a supramolecular conjugate that exploits the hydrophilic nature of the amino acid chain as a route through which the protective coating can be eroded and hence the underlying substrate exposed. The efficacy of the release process has been critically assessed with a view to establishing the action and selectivity of the trigger mechanism. (c) 2006 Elsevier Inc. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:14327
Deposited By:Professor James Davis
Deposited On:01 Jul 2010 09:14
Last Modified:18 Aug 2011 11:19

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