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Integration of Gene Ontology-based similarities for supporting analysis of protein–protein interaction networks

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Wang, HY, Zheng, Huiru, Browne, Fiona, Glass, DH and Azuaje, Francisco (2010) Integration of Gene Ontology-based similarities for supporting analysis of protein–protein interaction networks. Pattern Recognition Letters, 31 (14). pp. 2073-2082. [Journal article]

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URL: http://dx.doi.org/10.1016/j.patrec.2010.04.011

DOI: doi:10.1016/j.patrec.2010.04.011

Abstract

In recent years there has been a growing trend towards the inclusion of diverse genomic information to support comprehensive large-scale prediction of protein–protein interaction networks. The Gene Ontology (GO) is one such functional knowledge resource, which consists of three hierarchies to describe functional attributes of gene products: Molecular function, biological process, and cellular component. Using Bayesian networks, this paper presents a framework for the probabilistic combination of semantic similarity knowledge extracted from the three GO hierarchies for analysis of protein–protein interaction networks and demonstrates its application in yeast. The results indicate that by integrating information encoded in the GO hierarchies a better result can be achieved in terms of both statistical prediction capability and potential biological relevance.

Item Type:Journal article
Keywords:Gene ontology; Protein interaction networks; Bayesian networks; Classification
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Computing and Mathematics
Research Institutes and Groups:Computer Science Research Institute
Computer Science Research Institute > Artificial Intelligence and Applications
Computer Science Research Institute > Smart Environments
ID Code:14140
Deposited By:Dr Huiru Zheng
Deposited On:10 Sep 2010 14:38
Last Modified:08 Dec 2010 12:35

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