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A study of the antimicrobial activity of selected synthetic and naturally occurring quinolines

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

O'Donnell, F., Smyth, T. J. P., Ramachandran, V. N. and Smyth, Franklin (2010) A study of the antimicrobial activity of selected synthetic and naturally occurring quinolines. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 35 (1). pp. 30-38. [Journal article]

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DOI: 10.1016/j.ijantimicag.2009.06.031

Abstract

The antimicrobial activities of 60 naturally occurring and synthetic quinolines were studied. The quinolines were organised into seven structural subgroups and, using an in-house microtitre assay, were tested against a range of Gram-positive and Gram-negative bacteria, including a hospital isolate of meticillin-resistant Staphylococcus aureus (MRSA). The quinolines exhibiting good bioactivity [i.e. low minimum inhibitory concentration (MIC)] against two S. aureus strains were then assessed for their antimicrobial activity against a range of eight clinically isolated MRSA strains. The study showed that 30 of the tested compounds displayed antimicrobial activity, mostly against Gram-positive bacteria. The effects of substituent groups on the bioactivity of these quinolines have also been discussed. The quinoline 4-hydroxy-3-iodo-quinol-2-one (11) exhibited significant antimicrobial activity, being active against the MRSA clinical isolates with MIC values comparable with the antibiotic vancomycin used in the treatment of MRSA infections. In particular, 4-hydroxy-3-iodo-quinol-2-one (11) showed MIC values of 0.097 mu g/mL against an Irish hospital MRSA-1 strain and 0.049 mu g/mL against a distinct MRSA strain as well as a non-typeable MRSA strain. (c) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:13367
Deposited By:Prof W.Franklin Smyth
Deposited On:30 Apr 2010 10:08
Last Modified:04 May 2012 09:19

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