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COMPARISON OF THE DOMINANT FREQUENCY OF VENTRICULAR-FIBRILLATION, INDUCED UNDER DIFFERENT CONDITIONS IN THE ANESTHETIZED DOG

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

ADGEY, AAJ, ALLEN, JD, ANDERSON, J, CARLISLE, EJF and Kernohan, George (1986) COMPARISON OF THE DOMINANT FREQUENCY OF VENTRICULAR-FIBRILLATION, INDUCED UNDER DIFFERENT CONDITIONS IN THE ANESTHETIZED DOG. JOURNAL OF PHYSIOLOGY-LONDON, 381 . P24. [Journal article]

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URL: http://jp.physoc.org/content/381/supplement/13P.full.pdf+html

Abstract

Using power spectral analysis, we have examined the frequency content ofdifferent types of ventricular fibrillation (VF). Greyhound dogs were anaesthetizedwith sodium pentobarbitone (30-35 mg/kg i.v.) and ventilated with room air. Thee.c.g. of VF was recorded (lead 2, Hellige) with an A-D converter on cassette tape(Loughlin, 1983), and analysed offline by use of the Fast Fourier Transform (Brueland Kjaer Spectrum Analyzer Type 2031). The frequency limits (-3 dB) for thesystem were 04-55 Hz. The dominant frequency of the VF (1-41 s), induced in thespecified way, is given for each group (mean+s.E. of mean).In Group 1 the dominant frequency of VF after rapid electrical stimulation of thenormal heart was initially 99 ±0 7 Hz (N = 5: limb lead II), remained above 9 Hzfor 70 s, and then fell in the next 20 s to about 5 Hz. In contrast the frequency ofVF recorded from an endocardial catheter in the right ventricle (Group 1) remainedhigh for several minutes.In VF induced by the slow i.v. administration of ouabain (6-8 ± 1-3 Hz, N = 4), orthe rapid administration of KCl into the pulmonary artery (4-8 ± 0-8 Hz, N = 5), thedominant frequencies were always significantly lower than in Group 1 (P < 0 05).When VF developed after acute coronary occlusion (12-3 ±02 Hz, N = 9) thefrequency of VF recorded from an epicardial electrode over the ischaemic zone wassignificantly lower than that recorded from lead II. VF after reperfusion of acutelyischaemic myocardium (I2-2 ±04 Hz, N = 5), or electrical stimulation of the heartin the presence of acute ischaemia (11-7 ±0-5 Hz, N = 4), showed similar frequencies.Hyperkalaemia and toxic doses of ouabain, which reduce membrane potential,cause lower frequencies of fibrillation. This suggests that ionic movements throughfast Na channels may be required for the initially high frequencies seen in the otherforms of VF. As VF persists in the normal heart, a difference in frequency developsbetween the endocardium and the myocardium.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Nursing
Research Institutes and Groups:Institute of Nursing and Health Research
Institute of Nursing and Health Research > Managing Chronic Illness
ID Code:1320
Deposited By:Professor George Kernohan
Deposited On:11 Feb 2010 16:55
Last Modified:23 Jul 2012 14:52

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