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Electrochemical Monitoring of Singlet Oxygen Production

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Sharp, D, Forsythe, S and Davis, J (2009) Electrochemical Monitoring of Singlet Oxygen Production. ELECTROANALYSIS, 21 (21). pp. 2293-2296. [Journal article]

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DOI: 10.1002/elan.200904682

Abstract

The exploitation of singlet oxygen generating compounds as a means of targeted therapies drives the need to develop methods for assessing the efficacy of such compounds and their capacity for generating the reactive oxygen species. Degradation of diphenylisobenzofuran by singlet oxygen is widely used as a spectroscopic probe but its application can be problematic. An alternative detection strategy exploiting the electrochemical monitoring of the quencher concentration, by square wave voltammetry, has been shown to provide a more sensitive and flexible option that could be used to address the increasing interest in photosensitizing materials

Item Type:Journal article
Keywords:Singlet oxygen; Diphenylisobenzofuran; Photosensitizer; Tetraphenylporphyrin; Square wave voltammetry; Voltammetry; Medicinal chemistry
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:11889
Deposited By:Professor James Davis
Deposited On:14 Feb 2010 14:56
Last Modified:18 Aug 2011 11:18

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