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The effects of atomic force microscopy upon nominated living cells

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

O'Hagan, Barry, Doyle, P, Allen, James, Sutton, K and McKerr, George (2004) The effects of atomic force microscopy upon nominated living cells. ULTRAMICROSCOPY, 102 (1). pp. 1-5. [Journal article]

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DOI: 10.1016/j.ultramic.2004.06.009

Abstract

This work describes a system for precise re-location of cells within a monolayer after atomic force imaging. As we know little about probe interaction with soft biological surfaces any corroborative evidence is of great importance. For example, it is of paramount importance in living cell force microscopy that interrogated cells can be re-located and imaged by other corroborative technologies. Methodologies expressed here have shown that non-invasive force parameters can be established for specific cell types. Additionally, we show that the same sample can be transferred reliably to an SEM. Results here indicate that further work with live cells should initially establish appropriate prevailing force parameters and that cell damage should be checked for before and after an imaging experiment. (C) 2004 Elsevier B.V. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Nano Systems Biology
ID Code:11537
Deposited By:Dr G McKerr
Deposited On:17 Feb 2010 11:11
Last Modified:11 Aug 2010 15:28

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