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Design of a G-Quadruplex Topology through Glycosidic Bond Angles

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Webba da Silva, Mateus, Trajkovski, Marko, Sannohe, Yuta, Hessari, Nason, Sugiyama, Hiroshi and Plavec, Janez (2009) Design of a G-Quadruplex Topology through Glycosidic Bond Angles. Angewandte Chemie International Edition, 48 . [Journal article]

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URL: http://www3.interscience.wiley.com/journal/26737/home/2002_authors.html

DOI: 10.1002/anie.200902454

Abstract

To realize a programmed build up of DNA objects, devices,and materials, a systematization of the principles that formthe basis of control for the assembly process is necessary. Thusfar the discovery of four-stranded DNA architecturesdenominated G quadruplexes was either serendipitous orthrough coincidental emergence. Herein we utilize a rationalapproach for the design of G quadruplexes based on the twostatedisposition of the glycosidic bond angle.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Transcriptional Regulation & Epigenetics
ID Code:11481
Deposited By:Dr Mateus Webba da Silva
Deposited On:10 Feb 2010 09:50
Last Modified:04 Dec 2012 14:22

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