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In Vitro Antioxidant Activity and Antigenotoxic Effects of Avenanthramides and Related Compounds

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Lee-Manion, Alison M., Price, Ruth K., Strain, JJ, Dimberg, Lena H., Sunnerheim, Kerstin and Welch, RW (2009) In Vitro Antioxidant Activity and Antigenotoxic Effects of Avenanthramides and Related Compounds. Journal of Agricultural and Food Chemistry, 57 (22). pp. 10619-10624. [Journal article]

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DOI: 10.1021/jf9024739


Avenanthramides are substituted N-cinnamoylanthranilic acids, with hydroxycinnamic acid and anthranilic acid moieties. These alkaloid phenols, which are unique to oats, may confer health benefits via antioxidant or other mechanisms. Synthetic avenanthramides, hydroxycinnamic acids, Tranilast, and ascorbic acid were evaluated for antioxidant activity using two assays, DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (ferric reducing antioxidant potential), and for antigenotoxicity using the Comet assay with stressed human adenocarcinoma colon cells. Of all the compounds tested, N-(3',4'-dihydroxy-(E)-cinnamoyl)-5-hydroxyanthranilic acid (2c), an abundant oat avenanthramide, generally had the highest activity in all three assays. The drug Tranilast showed antigenotoxic effects, but not antioxidant activity, suggesting that antigenotoxicity is not dependent on antioxidant effects. Overall, results show that avenanthramides exert antioxidant and antigenotoxic activities that are comparable to those of ascorbic acid and which have the potential to exert beneficial physiological effects.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:11295
Deposited By:Professor Rob Welch
Deposited On:05 Feb 2010 09:30
Last Modified:21 Aug 2012 15:53

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